Should be a no. You need to determine what kind of connector the HD radio uses to connect to the car audio system. Our car does not have the standard CD changer plug or the standard antenna plug, although you could fashion an antenna plug yourself. You could do it via the FM modulator (which may just defeat purpose of HD) or the Dension GW500 for some models. The S40s with the in dash CD changer actually works via MOST / fiber optic cables, you would have to find one that does and is compatible.